ToxFAQs™ for Manganese

October 2012

CAS#: 7439-96-5

PDF Version, 107 KB

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This fact sheet answers the most frequently asked health questions (FAQs) about manganese. For more information, call the ATSDR Information Center at 1-800-232-4636. This fact sheet is one in a series of summaries about hazardous substances and their health effects. It is important you understand this information because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present.

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Highlights

Manganese is a trace element and eating a small amount from food or water is needed to stay healthy. Exposure to excess levels of manganese may occur from breathing air, particularly where manganese is used in manufacturing, and from drinking water and eating food. At high levels, it can cause damage to the brain. Manganese has been found in at least 869 of the 1,669 National Priorities List sites identified by the Environmental Protection Agency (EPA).

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What is manganese?

Manganese is a naturally occurring metal that is found in many types of rocks. Pure manganese is silver-colored, but does not occur naturally. It combines with other substances such as oxygen, sulfur, or chlorine. Manganese occurs naturally in most foods and may be added to some foods.

Manganese is used principally in steel production to improve hardness, stiffness, and strength. It may also be used as an additive in gasoline to improve the octane rating of the gas.

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What happens to manganese when it enters the environment?

• Manganese can be released to the air, soil, and water from the manufacture, use, and disposal of manganese-based products.
• Manganese cannot break down in the environment. It can only change its form or become attached to or separated from particles.
• In water, manganese tends to attach to particles in the water or settle into the sediment.
• The chemical state of manganese and the type of soil determine how fast it moves through the soil and how much is retained in the soil.
• The manganese-containing gasoline additive may degrade in the environment quickly when exposed to sunlight, releasing manganese.

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How might I be exposed to manganese?

• The primary way you can be exposed to manganese is by eating food or manganese-containing nutritional supplements. Vegetarians, who consume foods rich in manganese such as grains, beans and nuts, as well as heavy tea drinkers, may have a higher intake of manganese than the average person.
• Certain occupations like welding or working in a factory where steel is made may increase your chances of being exposed to high levels of manganese.
• Manganese is routinely contained in groundwater, drinking water, and soil at low levels. Drinking water containing manganese or swimming or bathing in water containing manganese may expose you to low levels of this chemical.

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How can manganese affect my health?

Manganese is an essential nutrient, and eating a small amount of it each day is important to stay healthy.

The most common health problems in workers exposed to high levels of manganese involve the nervous system. These health effects include behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. Other less severe nervous system effects such as slowed hand movements have been observed in some workers exposed to lower concentrations in the work place.

Exposure to high levels of manganese in air can cause lung irritation and reproductive effects.

Nervous system and reproductive effects have been observed in animals after high oral doses of manganese.

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How likely is manganese to cause cancer?

The EPA concluded that existing scientific information cannot determine whether or not excess manganese can cause cancer.

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How can manganese affect children?

Studies in children have suggested that extremely high levels of manganese exposure may produce undesirable effects on brain development, including changes in behavior and decreases in the ability to learn and remember. We do not know for certain that these changes were caused by manganese alone. We do not know if these changes are temporary or permanent. We do not know whether children are more sensitive than adults to the effects of manganese, but there is some indication from experiments in laboratory animals that they may be.

Studies of manganese workers have not found increases in birth defects or low birth weight in their offspring. No birth defects were observed in animals exposed to manganese.

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How can families reduce the risk of exposure to manganese?

• Children are not likely to be exposed to harmful amounts of manganese in the diet. However, higher-than-usual amounts of manganese may be absorbed if their diet is low in iron. It is important to provide your child with a well-balanced diet.
• Workers exposed to high levels of airborne manganese in certain occupational settings may accumulate manganese dust on their work clothes. Manganese-contaminated work clothing should be removed before getting into your car or entering your home to help reduce the exposure hazard for yourself and your family.

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Is there a medical test to determine whether I've been exposed to manganese?

Several tests are available to measure manganese in blood, urine, hair, or feces. Because manganese is normally present in our body, some is always found in tissues or fluids.

Because excess manganese is usually removed from the body within a few days, past exposures are difficult to measure with common laboratory tests.

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Has the federal government made recommendations to protect human health?

The EPA has determined that exposure to manganese in drinking water at concentrations of 1 mg/L for up to 10 days is not expected to cause any adverse effects in a child.

The EPA has established that lifetime exposure to 0.3 mg/L manganese is not expected to cause any adverse effects.

The FDA has determined that the manganese concentration in bottled drinking water should not exceed 0.05 mg/L.

The Occupational Health and Safety Administration (OSHA) has established a ceiling limit (concentration that should not be exceeded at any time during exposure) of 5 mg/m³ for manganese in workplace air.

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References

Agency for Toxic Substances and Disease Registry (ATSDR). 2012. Toxicological Profile for Manganese. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

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Where can I get more information?

If you have questions or concerns, please contact your community or state health or environmental quality department or:

For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30329-4027
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Email: Contact CDC-INFO

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.

Information line and technical assistance:
Phone: 888-422-8737

To order toxicological profiles, contact:
National Technical Information Service
5285 Port Royal Road
Springfield, VA 22161
Phone: 800-553-6847 or 703-605-6000

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Some PDF files may be electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.

The information contained here was correct at the time of publication. Please check with the appropriate agency for any changes to the regulations or guidelines cited.